Days Inn by Wyndham Picayune

Discover Picayune

Off I-59, close to the historical district

Book a room at our Days Inn-Picayune hotel near New Orleans, the perfect place to start your adventure in sunny Mississippi. Conveniently located off I-59 and Highway 43, we offer great value to help you get the most out of your next trip.

Comfortable Accommodations

Make a splash in our outdoor pool

Greet the morning with a free Daybreak continental breakfast with hot waffles. Keep active at our indoor fitness center and outdoor pool. Return to your room, complete with free WiFi, a microwave, and refrigerator. Hot tub suites, non-smoking, and accessible rooms are available. Free parking with many large-vehicle spaces available.

Spend the Day Your Way

See wildlife, visit the French Quarter, or play at the casino

Visit The Crosby Arboretum at Mississippi State University, which showcases the local ecosystem. Take a guided tour aboard a fan-boat at Honey Island Swamp to spot alligators and other wildlife. Take a short drive to the French Quarter in New Orleans and discover the unique cultural heritage of the area as you shop and dine. Roll the dice at Boomtown Casino in Biloxi, featuring classic table games and exciting slot machines.


Pool at the Days Inn by Wyndham Picayune in Picayune, Mississippi
Days Inn by Wyndham Picayune hotel lobby in Picayune, Mississippi
Guest room at the Days Inn by Wyndham Picayune in Picayune, Mississippi

Map & Directions

450 South Lofton Ave, Picayune, MS, 39466



Plan Your Group Travel With Us

Book your wedding party, sports team, or other group travel at our hotel. Submit your request for information about special rates on blocks of rooms.