Wyndham Garden Buffalo Downtown

A Stress-Free Stay in Buffalo

Inviting hotel on the Buffalo Niagara Medical Campus, near the airport

Welcome to Wyndham Garden Buffalo Downtown, a convenient and comfortable hotel located on the Buffalo Niagara Medical Campus. Connected via an indoor walkway, you’ll be steps from Buffalo General Hospital, Gates Vascular Institute, John R. Oishei Children’s Hospital, and Roswell Park Cancer Institute. You can explore the downtown area using our free local shuttle, or schedule a shuttle ride to or from Buffalo Niagara International Airport (BUF) for an additional fee. Plus, our friendly front desk staff is available 24/7 for directions and local recommendations.

Redefining Expectations

Enjoy our restaurant and bar—plus, free WiFi and our area shuttle

Join us at our American grill for a casual meal or sample local craft brews at the bar. Our fitness center makes it easy to keep up with your workouts, while the business center helps you stay productive. With our onsite laundry facilities, you can pack light and keep your wardrobe fresh throughout your stay. Each non-smoking guest room features free WiFi, a flat-screen TV with cable, mini-refrigerator, microwave, coffee and tea maker, safe, hair dryer, and desk. You can also take advantage of our valet parking for an additional fee or our free downtown area shuttle.

Explore Buffalo

Take it all in during your stay

There is so much to see and do in Buffalo, all just steps from our door. Visit historic sites and museums, catch a game, or learn about exotic wildlife at the zoo. There are also several local businesses in the area, making our hotel the perfect place for work or play.


Wyndham Garden Buffalo Downtown restaurant in Buffalo, New York
Bar at Wyndham Garden Buffalo Downtown in Buffalo, New York
Wyndham Garden Buffalo Downtown hotel lobby in Buffalo, New York

Map & Directions

125 High Street, Buffalo, NY, 14203



Carlton’s Grill

Enjoy breakfast classics like pancakes, home fries, and eggs, or treat yourself to American favorites such as burgers and wings for dinner. We also offer local beers on tap, so you can get a true taste of Buffalo’s craft brewery scene.

Breakfast 6–11 a.m.
Dinner 4–11 p.m.

Meetings, Events & Groups

The Perfect Space for Meetings & Events

Plan your next special event or business meeting with us. Featuring 1,745 square feet of event space, our hotel offers 4 meeting rooms that accommodate 202 conference guests or 50 banquet guests. We can also arrange great rates for groups of all sizes.